我公司致力于為客戶提供高純度、低成本的活性重組蛋白，包括重組人VSIG4在內(nèi)的各類受體、細胞因子、生長因子、轉(zhuǎn)錄因子、激素、酶、毒性蛋白、病毒抗原等。...

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產(chǎn)品名稱：重組人VSIG4(含V-set和Ig結(jié)構(gòu)域蛋白4)
英文名稱：Recombinant Human V-Set and Immunoglobulin Domain-Containing Protein 4
產(chǎn)品貨號：JN0620
產(chǎn)品規(guī)格：10μg|50μg|500μg|1mg

本品由我們的哺乳動物細胞表達系統(tǒng)制備而成，目的基因編碼的Arg20-Pro283在C端含有His標簽。

VSIG4質(zhì)量控制：＞95%(還原性SDS-PAGE)

VSIG4制劑：凍干品

VSIG4保存：
凍干蛋白置于-20℃以下可長期保存，室溫條件下可穩(wěn)定保存3周。
復溶蛋白溶液可在4～7℃保存2～7天，可分裝后置于-20℃保存三個月。

VSIG4復溶：
打開試劑管前請先離心。
復溶濃度推薦大于100 μg/ml。
凍干蛋白請溶于ddH2O。
復溶后，請根據(jù)用量分裝凍存，避免反復凍融。

關于VSIG4：
V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) is a 45-50 kDa macrophage-specific transmembrane glycoprotein that belongs to the B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type Ig domain and a truncated C-type Ig domain. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. It is also expressed in resting macrophages. No VSIG4 expression appears to be present in T and B cells. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. It is a potent inhibitor of the alternative complement pathway convertases. Human VSIG4 is 399 amino acids (aa) in length. It is a type I transmembrane (TM) glycoprotein that contains a 264 aa extracellular domain (ECD) (aa 20 - 283) and a 95 aa cytoplasmic region.

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名稱：重組長尾獼猴成纖維生長因子21
貨號：JN0285
規(guī)格：10μg|50μg|500μg|1mg
本品由我們的哺乳動物表達系統(tǒng)制備，目的基因編碼的His29-Ser209在C端含有His標簽。

FGF-21質(zhì)量控制：＞95%(還原性SDS-PAGE)。

FGF-21制劑：凍干品

FGF-21保存：
凍干蛋白可在-20℃長期保存，室溫也可穩(wěn)定保存3周。
復溶蛋白溶液可在4～7℃保存2～7天。
復溶后建議分裝凍存在-20℃，可保存3個月，應避免反復凍融。

FGF-21復溶：
1、試劑開蓋前請先離心。
2、復溶濃度應大于100 μg/ml.
3、凍干蛋白溶于ddH2O中
4、復溶后根據(jù)使用量分裝保存，避免反復凍融。

關于FGF-21：
Fibroblast Growth Factor 21 (FGF21) is a growth factor that belongs to the FGF family. FGF family proteins play a central role during prenatal development and postnatal growth and regeneration of mamy tissues, by promoting cellular proliferation and differentiation. FGF21 is a potent activator of glucose uptake on adipocytes, protects animal from diet-induced obesity when overexpression in transgenic mice, and lower blood glucose and triglyceride levels when therapeutically adiministered to diabetic redents. FGF21 is produced by hepatocytes in reponse to free fatty acid stimulation of a PPARa/RXR dimeric complex. This situation occurs clinically during starvation, or following the ingestionof a highly-fat/low-carbohydrate diet. Upon FGF21 secretion, white adipose tissue is induced to release free fatty acids from triglyceride stores. once free fatty acid reach hepatocytes, they are oxidized and reduced to acetyl-CoA. The acetyl-CoA is recombined into 4-carbon ketone bodies, release, and transported to peripheral tissue for TCA processing and energy generation.

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